Absci Corporation (NASDAQ: ABSI) Q2 2025 Earnings | 08/13/2025

7 days ago

39:07

Inside Ticker

Earnings Calls

AI Summary

Key Highlights:

Clinical Progress:
- ABS-101 (anti-TL1A antibody): Phase 1 trial ongoing (40 healthy volunteers); interim PK/PD and immunogenicity data expected late 2025. Potential for quarterly dosing and strong partner interest.
- ABS-201 (anti-prolactin receptor for hair loss): Phase 1/2a trial to initiate in early 2026, with interim efficacy data (hair regrowth) in H2 2026. Potential for subcutaneous formulation (2–3 doses over 6 months).
- ABS-301 (immuno-oncology) & ABS-501 (anti-HER2): Advancing toward IND-enabling studies; seeking large pharma partnerships for development.
AI Drug Creation Platform:
- Almirall partnership expanded to a second bispecific program (ion channel target); total potential milestones: $650M.
- Focus on difficult-to-drug targets (GPCRs, ion channels) with AI-designed antibodies.
- AMD collaboration ($20M investment) supports compute infrastructure.
Financials & Runway:
- Q2 revenue: $600K (partnered programs).
- Cash position: $117.5M (post-Q2) + $64M raised in July ($50M public offering + $14M ATM).
- Cash runway extended into H1 2028, with upside from potential partnerships/asset deals.
Business Development:
- Anticipated 2025 catalysts:
  - Large pharma partnership (platform or asset deal).
  - ABS-101 Phase 1 data (late 2025).
  - R&D Day (new pipeline programs, including GPCR/ion channel targets).
- ABS-201 could progress to Phase 2/3 by 2027, targeting BLA submission in 2030–2031.
Strategic Focus:
- Out-license oncology programs (ABS-301/501) early; develop ABS-201 internally through commercialization.
- Explore endometriosis as a secondary indication for ABS-201.

Q&A Highlights:

TL1A Competitive Landscape: SPIRE data (competitor) supports quarterly/semi-annual dosing; Absci emphasizes bispecific differentiation.
Hair Loss Trial Design: Controlled Phase 1/2a with hair density/terminal count endpoints; details at R&D Day.
Platform Differentiation: AI excels in de novo design for hard-to-drug targets (e.g., Almirall’s ion channel success).
Partnering Strategy: Revenue will be lumpy (milestone-driven); multiple pharma discussions ongoing.

Closing Remarks:
CEO Sean McLean highlighted Absci’s transition from preclinical to clinical-stage biotech, with ABS-101 and ABS-201 as near-term value drivers. The company is well-capitalized to advance its pipeline and platform, with multiple catalysts expected through 2026.

About this video

Absci Corporation (NASDAQ: ABSI), a biotech company pioneering AI-driven protein production and drug discovery platforms, reported its Q2 2025 financial results with key operational and strategic updates. The company achieved revenue of $600,000 for the quarter, a significant decline compared to prior periods, missing analyst expectations amid ongoing development focus. Research and development expenses increased to $20.5 million from $15.3 million in the prior year, reflecting expanded clinical and platform development activities. Absci's net loss widened to $30.6 million for the quarter, impacted by increased R&D spending and the strategic ramp-up of its AI-powered drug discovery pipeline. The company bolstered its financial position with a $64 million capital raise in July 2025, extending its cash runway into 2028. Cash, cash equivalents, and short-term investments totaled $117.5 million as of June 30, 2025, supporting ongoing clinical programs and partnership efforts. Strategic updates include the initiation of Phase I trials for ABS-101, an anti-TL1A antibody, with interim results expected later in 2025. Absci also plans Phase I/IIa trial initiation for ABS-201, an anti-prolactin receptor antibody targeting androgenetic alopecia, slated for early 2026 with interim data anticipated later that year. The company continues to pursue partnerships for ABS-301 and ABS-501 at earlier development stages. Risks highlighted involve high cash burn linked to research and development, competitive pressures in the biotech sector, and uncertainty surrounding clinical outcomes and partnership deals. About Inside Ticker: Inside Ticker delivers timely, in-depth financial news and earnings analysis to empower investors with actionable insights on global companies across sectors. For comprehensive video analysis and real-time updates, visit https://www.insideticker.com/. Hashtags: #Absci #ABSI #Q22025 #Earnings #FinancialResults #Revenue #NetLoss #RandD #ClinicalTrials #ABS101 #ABS201 #DrugDiscovery #AI #ProteinProduction #CapitalRaise #CashRunway #Biotech #Pharmaceuticals #StockMarket #NASDAQ #Innovation #Partnerships #Pipeline #Biotechnology #ClinicalDevelopment #GrowthStrategy #FinancialHealth #EarningsReport #InvestorRelations #BiotechNews #HealthcareInnovation #ResearchAndDevelopment #Q2Results #EarningsMiss #CashPosition #TechnologyDriven

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